MRd.synbio is an ingredient specifically formulated to enhance the properties of the unique phytocomplex derived from the proprietary variety of pigmented corn (Zea mays var. Moradyn® (L.)) combined with a specific polysaccharide component. Preclinical studies on MRd.synbio have demonstrated its ability to:
MRd.synbio is standardized to:
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CARDIOVASCULAR
HEALTH
GLUCOSE
MANAGEMENT
HEALTHY
BOWEL
The anthocyanins and flavonoids present in the MORADYN® phytocomplex exhibit strong antioxidant and notable antiglycative activities.
Preclinical studies on the MORADYN® extract demonstrated a significant antiglycative effect across all tested concentrations and time points. At a concentration of 1 mg/ml, the extract consistently achieved nearly 100% inhibition of glycation. [Ferron et al., 2020] Additionally, anthocyanins from purple corn showed potent antioxidant activity, with 95.7% DPPH radical-scavenging at 1 mg/ml. [Yang et al., 2010]
By reducing the activity of key enzymes involved in carbohydrate metabolism, the MORADYN® phytocomplex helps control postprandial hyperglycemia.
Preclinical data demonstrated a strong, dose-dependent inhibition of α-glucosidase by MORADYN®, with maximum inhibition of 97.38% at 1 mg/ml—significantly outperforming acarbose. [Ferron et al., 2020]The combination of anthocyanins and polysaccharides from Arabic gum effectively modulates the intestinal microbiota.
Anthocyanins promote the production of short-chain fatty acids (SCFAs), provide a carbon source, and help regulate intestinal pH, creating favorable conditions for microbiota growth. [Wang et al., 2022] MORADYN® bioactive compounds also enhance probiotic growth. In a 1:1 ratio, MORADYN® boosts the prebiotic effect of soluble fiber. [Independent University preclinical data]
CARDIOVASCULAR
HEALTH
Preclinical studies on the MORADYN® extract demonstrated a significant antiglycative effect across all tested concentrations and time points. At a concentration of 1 mg/ml, the extract consistently achieved nearly 100% inhibition of glycation. [Ferron et al., 2020] Additionally, anthocyanins from purple corn showed potent antioxidant activity, with 95.7% DPPH radical-scavenging at 1 mg/ml. [Yang et al., 2010]
GLUCOSE
MANAGEMENT
Preclinical data demonstrated a strong, dose-dependent inhibition of α-glucosidase by MORADYN®, with maximum inhibition of 97.38% at 1 mg/ml—significantly outperforming acarbose. [Ferron et al., 2020]
HEALTHY
BOWEL
Anthocyanins promote the production of short-chain fatty acids (SCFAs), provide a carbon source, and help regulate intestinal pH, creating favorable conditions for microbiota growth. [Wang et al., 2022] MORADYN® bioactive compounds also enhance probiotic growth. In a 1:1 ratio, MORADYN® boosts the prebiotic effect of soluble fiber. [Independent University preclinical data]
MRd.synbio is characterized by a peculiar phytocomplex with a unique pattern of anthocyanins and flavonols from MORADYN® pigmented corn variety, supported by a specific polysaccharide component, which has shown in a clinical trial to be effective in modulating intestinal microbiota and in preventing the main metabolic syndrome complaints
The clinical outcomes for MRd.synbio stem from SPATIALS3, an active synbiotic specifically developed for a clinical trial under the regional project of the same name. Synbiotic formulations, which combine probiotics with prebiotic ingredients, are known to support gastrointestinal health by promoting the growth of beneficial bacteria and helping meet dietary fiber requirements. SPATIALS3 synbiotic is primarily characterized by two core components:
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As an active synbiotic, MRd.synbio enhances the protection and viability of selected probiotic strains, contributing to the modulation of the intestinal microbiota and helping prevent complications related to metabolic syndrome.
ABOUT MORADYN®
The pigmented corn variety MORADYN® (Zea mays var. Moradyn® (L.)) was developed through traditional breeding techniques to create a high value-added nutritional profile, without altering its original genetic makeup. It is currently cultivated in Lombardy, in the flatlands of northern Italy. Its unique anthocyanin and flavonol composition has been thoroughly characterized, with cyanidin-3-dimalonylglucoside, cyanidin-3-glucoside (C3G), pelargonidin-3-glucoside, and peonidin-3-glucoside identified as the predominant anthocyanins.