PANAXOLYDE®: A better way to boost your gut health

Ginseng scientific genus name (“Panax”) shares the same semantic root of ancient Greek word “Panakeia”, which is the universal remedy Godness name. Ginseng pivotal role in traditional Chinese medicine was, in fact, well-known by Linneus when he named this exceptional Araliaceae family plant member.

It is recognized that ginseng has significative healthy effects on multiple factors implied in overall well-being such as glycemic control¹, cardiovascular function², central-nervous-system protection³ and immune response⁴.

The list of ginseng positive properties has been further enriched considering ginseng action on gut functionality and wellness.

A 2016 murine study⁵ shows that ginseng polysaccharides can rescue gut microbiota stress-induced alterations, improving on one hand ginsenosides bio-disponibility and on the other hand helping in restore the correct equilibrium between different intestine bacterial genus. Stress decreases beneficial microorganism variety and quantity (es: reduction of Bacteroides spp. e Lactobacillus spp.): ginseng polysaccharides can, therefore, enhance these positive symbionts growth⁵.

Inflammatory chronic conditions predispose the neoplasies formation, especially in the gastrointestinal traits. It has been proved that suppling alimentation with a daily dose of ginseng attenuates chemical-induced colitis and colon carcinogenesis in inflammatory bowel disease mice⁶.

REFERENCES

[1] Shishtar et al. 2014, The effect of ginseng (the genus panax) on glycemic control: a systematic review and meta-analysis of randomized controlled clinical trials, PloS One. 9(9):e107391
[2] Lee and Kim. 2014, A review on the medicinal potentials of ginsengand ginsenosides on cardiovascular disease, J Ginseng Res. 38(3):161-166
[3] Liao et al. 2002, Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg1 on spinal cord neurons in vitro, Exp Neurol. 173:224–234
[4] He at al. 2017,Ginseng (Panax ginseng Meyer) oligopeptides regulate innate and adaptive immune responses in mice via increased macrophage phagocytosis capacity, NK cell activity and Th cells secretion, Food Funct. 8(10):3523-3532
[5] Zhou et al. 2016, Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction, Nature Scientific Reports 6:22474
[6] Wang, et al. 2017, American Ginseng Attenuates Colitis Associated Colon Carcinogenesis in Mice: Impact on Gut Microbiota and Metabolomics, Cancer prevention research(Philadelphia, Pa.) 803–811